Three indications for implant-supported overdentures are defined, namely, the edentulous maxilla, the edentulous mandible, and the compromised situation. These indications for overdentures are related to three patient groups: (1) a younger segment of patients among the older population with maxillary complete dentures, (2) elderly completely edentulous patients who request better stabilization of the mandibular denture, and (3) patients with acquired or congenital defects. The aim of this article is to discuss treatment strategies and clinical considerations with respect to three specific indications for overdentures.