Silicone versus polymethylmethacrylate intraocular lenses with regard to capsular opacification

Ophthalmic Surg Lasers. 1998 Jan;29(1):55-8.


Background and objective: The authors conducted a 3-year randomized trial to compare silicone intraocular lenses (IOLs) with polymethylmethacrylate (PMMA) IOLs, to determine any differences in laser capsulotomy rates, capsular opacification light scatter, and subjective scoring.

Patients and methods: A total of 119 patients were enrolled, 84 of whom were examined at 3 years. The authors designed a prospective, masked, and randomized trial to compare the objective (lens opacity meter), subjective (slit-lamp scoring), and clinical parameters of the posterior capsular opacification (PCO) of these patients.

Results: The silicone group had less PCO than the PMMA group, according to objective (8.6% vs. 10.4%; P = .02, Student's t test) and subjective scoring (0.88 vs. 1.79; P = .0001, Student's t test). The laser capsulotomy rate was 24% for the silicone group and 33% for the PMMA group; however, this difference was not statistically significant.

Conclusion: The silicone IOL was associated with less PCO than the PMMA IOL.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cataract / etiology*
  • Cataract / pathology
  • Cataract Extraction
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Laser Therapy
  • Lens Capsule, Crystalline / pathology*
  • Lens Capsule, Crystalline / surgery
  • Lenses, Intraocular*
  • Male
  • Polymethyl Methacrylate / adverse effects*
  • Prospective Studies
  • Silicone Elastomers / adverse effects*
  • Visual Acuity


  • Silicone Elastomers
  • Polymethyl Methacrylate