Use and abuse of flunitrazepam

Ann Pharmacother. 1998 Jan;32(1):117-9. doi: 10.1345/aph.17027.


Flunitrazepam is not available in the US, and it is presently illegal to import it. Flunitrazepam has no therapeutic advantage over benzodiazepines presently marketed in the US. Its quick onset of sedation, amnesic properties, and additive effects with alcohol have led to its reputation as a party drug, club drug, or date rape drug. Several measures have been undertaken to curb its illicit use. It is unclear whether flunitrazepam poses a greater public health risk than other benzodiazepines.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Anti-Anxiety Agents* / administration & dosage
  • Anti-Anxiety Agents* / pharmacokinetics
  • Anti-Anxiety Agents* / therapeutic use
  • Anti-Anxiety Agents* / urine
  • Flunitrazepam* / administration & dosage
  • Flunitrazepam* / pharmacokinetics
  • Flunitrazepam* / therapeutic use
  • Flunitrazepam* / urine
  • Humans
  • Substance Abuse Detection
  • Substance-Related Disorders* / physiopathology
  • Tablets


  • Anti-Anxiety Agents
  • Tablets
  • Flunitrazepam