Plasma interleukin-3 (IL-3) and IL-7 concentrations in children with homozygous beta-thalassemia

J Trop Pediatr. 1997 Dec;43(6):366-7. doi: 10.1093/tropej/43.6.366.


Plasma levels of IL-3 and IL-7 were studied in 23 patients with homozygous beta-thalassemia in order to determine whether these cytokines are involved in abnormalities in erythropoiesis and immune responses as observed in thalassemic patients. No significant difference was found in plasma IL-7 concentrations between thalassemic patients and healthy controls and it was suggested that IL-7 is not a cytokine involved in cellular immunological alterations in beta-thalassemia. However, the number of thalassemic patients with detectable IL-3 concentrations was significantly higher. It was concluded that IL-3 production has to be studied in detail in order to learn more about the involvement of this cytokine in erythropoiesis of thalassemic patients.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Chi-Square Distribution
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Erythropoiesis / immunology
  • Female
  • Homozygote
  • Humans
  • Immunity, Cellular / physiology
  • Interleukin-3 / biosynthesis
  • Interleukin-3 / blood*
  • Interleukin-7 / biosynthesis
  • Interleukin-7 / blood*
  • Male
  • Sensitivity and Specificity
  • beta-Thalassemia / genetics
  • beta-Thalassemia / immunology*


  • Interleukin-3
  • Interleukin-7