Hippocampus and parahippocampal gyrus linear measurements based on magnetic resonance in Alzheimer's disease

Eur Neurol. 1998;39(1):16-25. doi: 10.1159/000007893.


MRI-based linear measurements of the hippocampus and parahippocampal gyrus complex (HPC) discriminated 39 subjects with probable Alzheimer's disease, from 15 patients with other dementias and 33 miscellaneous controls without evidence of dementia. The best discriminating parameter was the left height of the HPC at the level of the mammillary bodies, with a sensitivity of 79.49% and a specificity of 68.75%. The diagnostic value of these results is discussed considering the volumetric data found in the current literature.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis*
  • Analysis of Variance
  • Biometry
  • Cognition Disorders / diagnosis
  • Female
  • Gyrus Cinguli / pathology*
  • Hippocampus / pathology*
  • Humans
  • Linear Models
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • ROC Curve
  • Reproducibility of Results
  • Sex Distribution