Suppression of growth and transformation and induction of apoptosis by EGR-1

Cancer Gene Ther. Jan-Feb 1998;5(1):3-28.

Abstract

Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor beta-1 (TGF-beta1) gene and cooperation with Sp1, Jun-B, p21WAF1/Cip1, and stimulates apoptosis by transactivation of the p53 gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Cell Transformation, Neoplastic*
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / physiology*
  • Early Growth Response Protein 1
  • Humans
  • Immediate-Early Proteins*
  • Transcription Factors / genetics*
  • Transcription Factors / physiology*
  • Transcriptional Activation
  • Transforming Growth Factor beta / genetics
  • Zinc Fingers

Substances

  • DNA-Binding Proteins
  • EGR1 protein, human
  • Early Growth Response Protein 1
  • Immediate-Early Proteins
  • Transcription Factors
  • Transforming Growth Factor beta