Benign metastasizing chondroblastoma: a case report

Cancer. 1998 Feb 15;82(4):675-8.


Background: Metastasis of histologically benign chondroblastoma is a rare event. The authors report a new case, 12th in the literature, wherein multiple lung metastases appeared almost simultaneously with the primary lesion in the right talus bone.

Methods: A histologic evaluation of the primary lesion in the talus and the pulmonary metastasis was performed, and an ultrastructural study of the latter was done. Published literature on metastasizing chondroblastoma was reviewed to identify any consistency in the pattern and the outcome.

Results: Metastasis of chondroblastoma is uncommon but well known. Although radiologic and histologic aggressive features have been sought, they do not necessarily correlate with the outcome.

Conclusions: Metastasis in chondroblastoma has been insufficiently stressed in the literature, unlike metastasis in giant cell tumors. The purpose of this case report is not only to document this uncommon event (the 12th case of lung metastasis) but also to emphasize that patients with chondroblastoma may have metastasis at presentation. Hence, all patients need to be evaluated regularly from the onset for possible lung metastasis so that deposits can be detected early for total resection.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / pathology*
  • Bone Neoplasms / surgery
  • Cell Nucleus / ultrastructure
  • Chondroblastoma / diagnostic imaging
  • Chondroblastoma / pathology
  • Chondroblastoma / secondary*
  • Chondroblastoma / surgery
  • Female
  • Giant Cells / ultrastructure
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / secondary*
  • Lung Neoplasms / surgery
  • Lung Neoplasms / ultrastructure
  • Osteoclasts / cytology
  • Radiography, Thoracic
  • Talus / diagnostic imaging
  • Talus / pathology
  • Thoracotomy