Platelet activating factor antagonist activity of ginsenosides

Biol Pharm Bull. 1998 Jan;21(1):79-80. doi: 10.1248/bpb.21.79.

Abstract

Ginseng saponins and their degradation products have been screened for antagonist activity towards [3H]PAF (platelet activating factor) in washed rabbit platelet receptor binding studies. 20(S)- and delta20-ginsenosides Rg3, protopanaxadiol-type saponins, were found to be relatively potent PAF antagonists (IC50 = 4.9 x 10(-5) M and 9.2 x 10(-5) M, respectively).

MeSH terms

  • Animals
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism
  • Buffers
  • Ginsenosides
  • In Vitro Techniques
  • Indicators and Reagents
  • Panax / chemistry*
  • Plants, Medicinal*
  • Platelet Activating Factor / antagonists & inhibitors*
  • Platelet Membrane Glycoproteins / metabolism
  • Rabbits
  • Receptors, Cell Surface*
  • Receptors, G-Protein-Coupled*
  • Saponins / pharmacology*

Substances

  • Buffers
  • Ginsenosides
  • Indicators and Reagents
  • Platelet Activating Factor
  • Platelet Membrane Glycoproteins
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Saponins
  • platelet activating factor receptor