Abstract
Ginseng saponins and their degradation products have been screened for antagonist activity towards [3H]PAF (platelet activating factor) in washed rabbit platelet receptor binding studies. 20(S)- and delta20-ginsenosides Rg3, protopanaxadiol-type saponins, were found to be relatively potent PAF antagonists (IC50 = 4.9 x 10(-5) M and 9.2 x 10(-5) M, respectively).
MeSH terms
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Animals
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Blood Platelets / drug effects
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Blood Platelets / metabolism
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Buffers
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Ginsenosides
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In Vitro Techniques
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Indicators and Reagents
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Panax / chemistry*
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Plants, Medicinal*
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Platelet Activating Factor / antagonists & inhibitors*
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Platelet Membrane Glycoproteins / metabolism
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Rabbits
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Receptors, Cell Surface*
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Receptors, G-Protein-Coupled*
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Saponins / pharmacology*
Substances
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Buffers
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Ginsenosides
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Indicators and Reagents
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Platelet Activating Factor
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Platelet Membrane Glycoproteins
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Receptors, Cell Surface
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Receptors, G-Protein-Coupled
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Saponins
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platelet activating factor receptor