Triplex-directed modification of genes and gene activity

Trends Biochem Sci. 1998 Jan;23(1):4-9. doi: 10.1016/s0968-0004(97)01158-4.


Oligonucleotides offer enormous potential for manipulating gene function in cells and, as such, constitute a promising new class of pharmaceutical agents. Oligonucleotides that form triple helices (triplexes) at specific DNA sequences in defined genes can be used to reduce transcription selectively, to introduce site-specific mutations or to stimulate gene-specific targeted recombination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression
  • Genetic Therapy*
  • Humans
  • Models, Molecular
  • Nucleic Acid Conformation*
  • Oligonucleotides / chemical synthesis
  • Oligonucleotides / chemistry
  • Oligonucleotides / therapeutic use*


  • Oligonucleotides