Chromatin remodeling machines: similar motors, ulterior motives

Trends Biochem Sci. 1998 Jan;23(1):20-5. doi: 10.1016/s0968-0004(97)01160-2.


Chromatin is a dynamic material; chromatin structures can repress transcription and their remodeling accompanies activation. Recent biochemical studies in Drosophila have revealed three multi-protein complexes with ATP-dependent chromatin restructuring activities. Although all contain the ATPase ISWI, their properties in vitro are markedly different, distinct from SWI-SNF and reveal intriguing connections to both transcription and chromatin assembly.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / physiology
  • Animals
  • Chromatin / physiology*
  • Humans
  • Models, Genetic
  • Molecular Sequence Data
  • Transcription Factors / physiology


  • Chromatin
  • ISWI protein
  • Transcription Factors
  • Adenosine Triphosphatases