Structural insights into DNA polymerase beta fidelity: hold tight if you want it right

Chem Biol. 1998 Jan;5(1):R7-13. doi: 10.1016/s1074-5521(98)90081-3.


DNA polymerases must select and incorporate the correct deoxynucleoside 5'-triphosphate from a pool of structurally similar molecules. The structural and kinetic characterization of DNA polymerase beta indicates that this polymerase must stabilize the templating base to achieve efficient polymerization with high fidelity.

MeSH terms

  • Binding Sites
  • Crystallography, X-Ray
  • DNA / biosynthesis
  • DNA Polymerase beta / chemistry*
  • DNA Polymerase beta / metabolism
  • DNA Replication
  • Deoxyribonucleotides / chemistry*
  • Models, Molecular*
  • Protein Conformation


  • Deoxyribonucleotides
  • DNA
  • DNA Polymerase beta