Is there a link between periodontal disease and coronary heart disease?

Br Dent J. 1998 Jan 10;184(1):33-8. doi: 10.1038/sj.bdj.4809536.


Objective: To provide a critical review of the studies completed to date that have investigated a link between coronary heart disease and dental health.

Design: Retrospective analysis.

Setting: Mainly hospital-based patients or subjects involved in longitudinal health care studies.

Main outcome measures: The incidence of coronary heart disease and its relationship to dental health and other recognised risk factors.

Results: Evidence suggests that dental health, in particular periodontal disease, may be a significant risk factor for coronary heart disease and further coronary events. Possible biological mechanisms that link the two diseases are appraised.

Conclusions: There does appear to be increasing evidence that a relationship exists between dental health and coronary heart disease, especially in males aged 40-50 years. The presence of a hyperinflammatory monocyte phenotype may provide a common biological mechanism that links the two diseases.

Publication types

  • Meta-Analysis

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Biology
  • Causality
  • Cerebrovascular Disorders / epidemiology
  • Cerebrovascular Disorders / physiopathology
  • Coronary Disease / epidemiology*
  • Coronary Disease / physiopathology
  • Dentist-Patient Relations
  • Female
  • Focal Infection, Dental / epidemiology
  • Focal Infection, Dental / physiopathology
  • Gram-Negative Bacteria / physiology
  • Hemostasis / physiology
  • Humans
  • Incidence
  • Inflammation Mediators / metabolism
  • Liability, Legal
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Monocytes / metabolism
  • Monocytes / physiology
  • Motivation
  • Periodontal Diseases / epidemiology*
  • Periodontal Diseases / physiopathology
  • Phenotype
  • Retrospective Studies
  • Risk Factors
  • Sex Factors
  • Thromboembolism / epidemiology
  • Thromboembolism / physiopathology
  • Tooth Extraction


  • Inflammation Mediators