[Effect of chromium yeast and chromium picolinate on body composition of obese, non-diabetic patients during and after a formula diet]

Acta Med Austriaca. 1997;24(5):185-7.
[Article in German]


The objective of this study was to assess the effects of chromium yeast and chromium picolinate on lean body mass during and after weight reduction with a very-low-calorie diet. 36 obese (BMI 33.7 +/- 5.4 kg/m2), non-diabetic patients aged 45 +/- 6 years undergoing a 8-week very-low-calorie diet followed by a 18-week maintenance period. During the whole 26 week treatment period subjects received either placebo or chromium yeast (200 micrograms/d) or chromium-picolinate (200 micrograms/d) in a double-blind manner. Body weight was measured as BMI and body composition after calculation from skinfold thickness. As a result all three groups showed comparable weight loss after 8 and 26 weeks. Lean body mass was reduced in all groups after 8 weeks. However, after 26 weeks chromium picolinate supplemented subjects showed increased lean body mass (p < 0.029) whereas the other treatment groups still had reduced lean body mass. Chromium picolinate, but not chromium yeast, is able to increase lean body mass in obese patients in the maintenance period after a very-low-calorie diet without counteracting the weight loss achieved.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Body Composition / drug effects*
  • Body Mass Index
  • Body Weight / drug effects
  • Chromium / pharmacology*
  • Diet, Reducing*
  • Double-Blind Method
  • Female
  • Food, Formulated*
  • Humans
  • Male
  • Middle Aged
  • Obesity / diet therapy*
  • Picolinic Acids / pharmacology*
  • Yeast, Dried*


  • Picolinic Acids
  • Chromium
  • picolinic acid