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, 32 (1), 18-22

Observations on the Use of Medetomidine/Ketamine and Its Reversal With Atipamezole for Chemical Restraint in the Mouse

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Observations on the Use of Medetomidine/Ketamine and Its Reversal With Atipamezole for Chemical Restraint in the Mouse

J I Cruz et al. Lab Anim.

Abstract

Ketamine and medetomidine produced chemical restraint for minor procedures in mice. Male mice required 50 mg/kg ketamine, 10 mg/kg medetomidine intraperitoneally (i.p.), and females a higher dose of ketamine (75 mg/kg i.p.). The onset of restraint effects, judged by loss of righting reflex, was more rapid in males than females. The effects were reversed using atipamezole (1-2.5 mg/kg). Recovery following administration of atipamezole was more rapid in males than females. We conclude that ketamine/medetomidine, followed by reversal with atipamezole, is an effective technique for chemical restraint in the mouse.

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