The apolipoprotein CI A allele as a risk factor for Alzheimer's disease

Neurochem Res. 1998 Mar;23(3):361-7. doi: 10.1023/a:1022409617539.


The E4 allele for the apolipoprotein E gene has been shown to be a significant risk factor for Alzheimer's disease. The gene is located in a conserved gene cluster on chromosome 19q12-13.2. Downstream from APOE is the gene for apolipoprotein CI. We had previously shown that the presence of a restriction site in the 5'end of APOCI (the A allele) was present at increased frequency in Alzheimer's patients and could also be considered as a risk factor for the disease. We have extended these studies and find that both familial and sporadic cases of Alzheimer's disease have a higher frequency of the APOCI A allele than control spouses. In addition, male patients with the APOCI A allele and/or the APOE4 allele tend to have an earlier age of onset of the disease than female patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Alleles*
  • Alzheimer Disease / genetics*
  • Apolipoprotein C-I
  • Apolipoprotein E4
  • Apolipoproteins C / genetics*
  • Apolipoproteins E
  • Deoxyribonucleases, Type II Site-Specific
  • Female
  • Gene Frequency
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymerase Chain Reaction
  • Risk Factors
  • Sex Factors


  • Apolipoprotein C-I
  • Apolipoprotein E4
  • Apolipoproteins C
  • Apolipoproteins E
  • endodeoxyribonuclease HpaI
  • Deoxyribonucleases, Type II Site-Specific