Plant O-methyltransferases: molecular analysis, common signature and classification

Plant Mol Biol. 1998 Jan;36(1):1-10. doi: 10.1023/a:1005939803300.

Abstract

Comparative analysis of the predicted amino acid sequences of a number of plant O-methyltransferase cDNA clones show that they share some 32-71% sequence identity, and can be grouped according to the different compounds they utilise as substrates. Five highly conserved regions are proposed as a signature for plant O-methyltransferases, two of which (regions I and IV) are believed to be involved in S-adenosyl-L-methionine and metal binding, respectively. The glycine-rich signature regions include a 36 amino acid domain which is located in the mid-terminal section of the carboxy terminus of most O-methyltransferase sequences. Cladistic analysis of the amino acid sequences suggests that plant O-methyltransferases may have arisen from common ancestral genes that were driven by different structural and/or functional requirements, and whose descendants segregated into different biochemical species. A comprehensive classification of plant O-methyltransferases is proposed following the guidelines of the Commission of Plant Gene Nomenclature.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Conserved Sequence
  • DNA, Complementary
  • Methyltransferases / chemistry
  • Methyltransferases / classification
  • Methyltransferases / genetics*
  • Phylogeny
  • Plants / classification
  • Plants / enzymology*
  • Plants / genetics*
  • Sequence Alignment

Substances

  • DNA, Complementary
  • Methyltransferases