The slow axonal transport of cytoskeletal proteins

Curr Opin Cell Biol. 1998 Feb;10(1):87-92. doi: 10.1016/s0955-0674(98)80090-2.

Abstract

Once presumed to be relatively uniform, the axonal cytoskeleton can vary markedly in size and composition along its length. New studies emphasize the interactiveness of neurofilaments and identify a family of cytoskeletal proteins that may cross-link the various cytoskeletal polymers of the axon, and anchor this network to the membrane skeleton. These and other findings support a model of the axonal cytoskeleton as a stationary but dynamic structure. Current evidence continues to support the possibility that axonally transported polymers/oligomers and/or monomers may serve as precursors to the cytoskeleton in different situations. Although the motors for slow transport of cytoskeletal proteins remain elusive, possible candidates are emerging.

Publication types

  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism
  • Animals
  • Axonal Transport / physiology*
  • Cytoskeletal Proteins / metabolism*
  • Humans
  • Microtubules / metabolism

Substances

  • Cytoskeletal Proteins