A prospective randomized study of wound approximation with tissue glue in circumcision in children

J Paediatr Child Health. 1997 Dec;33(6):515-6. doi: 10.1111/j.1440-1754.1997.tb01661.x.


Objective: Bleeding and wound infection are the most common complications of circumcision. Cyanoacrylate tissue glue has been claimed to have the advantage of being haemostatic, bacteriostatic and easy to use. The purpose of this study is to assess the feasibility of using the tissue glue in approximation of circumcision wound in children.

Methodology: A prospective randomized trial was carried out on 86 boys consecutively admitted into the Duchess of Kent Children's Hospital, Hong Kong. The results of wound approximation with cyanoacrylate tissue glue and suturing with interrupted 4/0 plain catgut were compared. The operations were carried out by the same surgeon using identical technique except for the wound approximation. The wound was assessed 1 day, 2 days, 3 days, 1 week and 1 month postoperatively.

Results: There was no statistically significant difference between the two groups in the rates of wound inflammation, infection, bleeding, dehiscence and cosmetic appearance, but the duration of operation was longer using tissue glue (19.8 min vs 16.5 min, P = 0.002).

Conclusions: We conclude that tissue glue approximation of circumcision wounds in children is a feasible alternative, but it offers no extra advantage when compared to suturing.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Child
  • Child, Preschool
  • Circumcision, Male / methods*
  • Enbucrilate*
  • Humans
  • Infant
  • Male
  • Postoperative Complications / prevention & control*
  • Prospective Studies
  • Sutures


  • Enbucrilate