Contributions of the American Journal of Physiology to the discovery of insulin

Am J Physiol. 1998 Feb;274(2):E207-9. doi: 10.1152/ajpendo.1998.274.2.E207.


Since its inception in 1898 the American Journal of Physiology has been a leader in diabetes research and has published many key articles on the subject. The Journal first published studies of phlorhizin-induced diabetes in 1898, and after many other contributions went on to publish the first reports of Banting, Best, Macleod, and Collip in 1922 concerning the isolation and purification of insulin (5-8, 13). This review highlights some of these key contributions of the Journal.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • History, 18th Century
  • History, 19th Century
  • History, 20th Century
  • Humans
  • Insulin / history*
  • Insulin / physiology
  • Periodicals as Topic


  • Insulin