Her, a gene required for sexual differentiation in Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy

Development. 1998 Jan;125(2):225-35. doi: 10.1242/dev.125.2.225.


The zygotic function of the hermaphrodite (her) gene of Drosophila plays an important role in sexual differentiation. Our molecular genetic characterization of her suggests that her is expressed sex non-specifically and independently of other known sex determination genes and that it acts together with the last genes in the sex determination hierarchy, doublesex and intersex, to control female sexual differentiation. Consistent with such a terminal function in sexual differentiation, her encodes a protein with C2H2-type zinc fingers. The her zinc fingers are atypical and similar to the even-numbered zinc fingers of ZFY and ZFX proteins in humans and other vertebrates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abdominal Muscles
  • Amino Acid Sequence
  • Animals
  • Animals, Genetically Modified
  • Base Sequence
  • Caenorhabditis elegans Proteins*
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics
  • Drosophila / embryology*
  • Drosophila / genetics
  • Drosophila Proteins*
  • Female
  • Gene Expression Regulation, Developmental
  • Genes, Insect / genetics
  • Genes, Insect / physiology
  • Helminth Proteins / genetics*
  • Insect Proteins / genetics
  • Male
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics
  • RNA Splicing
  • RNA, Messenger / analysis
  • Sequence Analysis, DNA
  • Sex Determination Processes*
  • Sex Differentiation / genetics*
  • Transcription Factors / genetics
  • Zinc Fingers*


  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • DSX protein, Drosophila
  • Drosophila Proteins
  • Helminth Proteins
  • Insect Proteins
  • Nerve Tissue Proteins
  • RNA, Messenger
  • Transcription Factors
  • fru protein, Drosophila
  • her-1 protein, C elegans

Associated data

  • GENBANK/AF025540