Transpupillary thermotherapy: results in 50 patients with choroidal melanoma

Arch Ophthalmol. 1998 Feb;116(2):157-62. doi: 10.1001/archopht.116.2.157.


Objective: To evaluate the efficacy and safety of transpupillary thermotherapy in treating choroidal melanoma.

Methods and patients: To perform transpupillary thermotherapy, infrared diode laser energy at 810 nm was used with a beam diameter of about 3 mm and 1-minute exposure time. All 50 patients had choroidal melanoma. We performed transpupillary thermotherapy in 21 tumors that had responded insufficiently to 800 Gy ruthenium 106 brachytherapy; it was combined with 800 Gy106Ru brachytherapy for 10 tumors greater than 5 mm in height and with 600 Gy for 19 tumors 5 mm or less in height.

Results: All but 1 tumor exhibited reduction in tumor height within a mean follow-up of 20.5 months (range, 6-49 months). In 41 eyes (82%), the tumor flattened completely. Visual acuity was 20/60 or better in 43 eyes (86%) before treatment and in 14 eyes (28%) at the last examination because of radiation vasculopathy. Neovascular glaucoma developed in 1 eye, and total retinal detachment developed in 2 eyes. Tumor recurrence was observed in 1 patient.

Conclusions: Although long-term results are necessary to properly appraise this new therapy, transpupillary thermotherapy may be useful as a complementary modality to brachytherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brachytherapy
  • Choroid Neoplasms / therapy*
  • Combined Modality Therapy
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Hyperthermia, Induced*
  • Laser Therapy
  • Male
  • Melanoma / therapy*
  • Middle Aged
  • Pupil
  • Ruthenium Radioisotopes
  • Safety


  • Ruthenium Radioisotopes