Antimalarial xanthones from Garcinia cowa

Planta Med. 1998 Feb;64(1):70-2. doi: 10.1055/s-2006-957370.

Abstract

Five xanthones from the bark of Garcinia cowa, namely 7-O-methylgarcinone E (1), cowanin (2), cowanol (3), cowaxanthone (4), and beta-mangostin (5), were found to possess in vitro antimalarial activity against Plasmodium falciparum with IC50 values ranging from 1.50 to 3.00 micrograms/ml. Complete 1H- and 13C-NMR assignments of these compounds are also reported.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemistry
  • Antimalarials / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects*
  • Xanthenes / chemistry
  • Xanthenes / pharmacology*
  • Xanthones*

Substances

  • Antimalarials
  • Xanthenes
  • Xanthones
  • xanthone