Abstract
Five xanthones from the bark of Garcinia cowa, namely 7-O-methylgarcinone E (1), cowanin (2), cowanol (3), cowaxanthone (4), and beta-mangostin (5), were found to possess in vitro antimalarial activity against Plasmodium falciparum with IC50 values ranging from 1.50 to 3.00 micrograms/ml. Complete 1H- and 13C-NMR assignments of these compounds are also reported.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry
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Antimalarials / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plants, Medicinal / chemistry*
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Plasmodium falciparum / drug effects*
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Xanthenes / chemistry
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Xanthenes / pharmacology*
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Xanthones*
Substances
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Antimalarials
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Xanthenes
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Xanthones
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xanthone