Brainstem involvement in a child with ophthalmoplegia, ataxia, areflexia syndrome

Pediatr Neurol. 1998 Jan;18(1):73-5. doi: 10.1016/s0887-8994(97)00141-0.


The anatomic location and pathogenesis of the ophthalmoplegia, ataxia, areflexia syndrome, which includes both the Miller-Fisher syndrome and Bickerstaff's brainstem encephalitis, continues to be a matter for debate. A patient with this syndrome is reported, and the brainstem location of the lesion and elevated titers of anti-GM1 antibodies in serum are demonstrated.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / blood*
  • Brain Stem / physiopathology*
  • Child, Preschool
  • G(M1) Ganglioside / immunology*
  • Humans
  • Male
  • Miller Fisher Syndrome / immunology
  • Miller Fisher Syndrome / physiopathology*


  • Autoantibodies
  • G(M1) Ganglioside