Mediators of inflammation

Curr Opin Immunol. 1997 Dec;9(6):851-7. doi: 10.1016/s0952-7915(97)80189-6.


Therapeutic studies and genetically engineered animals have elucidated the inflammatory roles of cytokines and chemokines in autoimmune disease. Most unexpected has been a continuum of recent evidence demonstrating that inflammatory mediators are crucial in lymphoid organ development, thus suggesting that these hitherto unrelated processes have common elements with implications for determinant spreading.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Autoimmune Diseases / immunology*
  • B-Lymphocytes / immunology
  • Cytokines / immunology*
  • Inflammation / immunology*
  • Th1 Cells / immunology
  • Th2 Cells / immunology


  • Cytokines