The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?

J Membr Biol. 1998 Feb 1;161(3):207-13. doi: 10.1007/s002329900327.


The existence of diversity in the voltage activated Ca2+ channel populations of vertebrate cells has been long recognized. More recently, the molecular cloning of a considerable number of Ca2+ channel subunits from cDNA libraries has indicated that the range of possible Ca2+ channel phenotypes a cell can express may be even greater than was previously appreciated. A challenge of recent years has been to resolve how the properties of recombinant channels correspond with their counterparts experimentally characterized in native cells. In this short review I will outline the properties of both native and recombinant Ca2+ channels, and will then describe the current agreements and controversies concerning their relationships to each other.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium Channels / genetics*
  • Cloning, Molecular
  • Electrochemistry
  • Genetic Variation*
  • Ion Channel Gating*
  • Phenotype


  • Calcium Channels