Spontaneous splenic rupture in infectious mononucleosis: a review

Yale J Biol Med. 1997 Mar-Apr;70(2):175-82.


Spontaneous rupture of the spleen is a rare complication of infectious mononucleosis (IM) occurring in 0.1-0.5 percent of patients with proven IM [1]. Although splenectomy has been advocated as the definitive therapy in the past, numerous recent reports have documented favorable outcomes with non-operative management. A review of the literature suggests that non-operative management can be successful if appropriate criteria, such as hemodynamic stability and transfusion requirements are applied in patient selection. We report the case of a 36 year old man with infectious mononucleosis who had a spontaneous splenic rupture and who was successfully managed by splenectomy. Based on review of the literature, an approach to management of a spontaneously ruptured spleen secondary to IM is suggested.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Female
  • Humans
  • Infectious Mononucleosis / complications*
  • Male
  • Splenectomy / adverse effects
  • Splenic Rupture / pathology
  • Splenic Rupture / surgery*
  • Splenic Rupture / therapy*