Behavioural sensitization in 6-hydroxydopamine-lesioned rats is related to compositional changes of the AP-1 transcription factor: evidence for induction of FosB- and JunD-related proteins

Brain Res Mol Brain Res. 1997 Dec 15;52(2):307-17. doi: 10.1016/s0169-328x(97)00253-2.


Rats with unilateral dopamine denervation exhibit turning behaviour in response to the selective D1 agonist SKF 38393 only after a previous exposure to dopamine agonists. We demonstrate here that this 'priming' phenomenon is related to both an increased expression of the pre-existing AP-1 complex and the occurrence of novel AP-1 complexes which are formed by FosB- and JunD-related proteins. While the former protein is expressed as a consequence of the dopamine denervation, the latter is related to the first exposure to a dopamine agonist. Pre-treatment with MK-801, an antagonist for glutamatergic receptors, prevents both the priming development and the AP-1 compositional changes. Rotational behaviour induced by SKF 38393 closely correlates with the presence of the priming AP-1 complexes, regardless of the capability of the D1 agonist to induce the immediate-early gene cFos.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology*
  • Animals
  • Benserazide / pharmacology*
  • Cell Nucleus / metabolism
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Denervation
  • Dizocilpine Maleate / pharmacology
  • Gene Expression Regulation / drug effects*
  • Levodopa / pharmacology*
  • Male
  • Motor Activity / drug effects
  • Motor Activity / physiology*
  • Neurons / drug effects
  • Neurons / metabolism*
  • Oxidopamine
  • Proto-Oncogene Proteins c-fos / biosynthesis*
  • Proto-Oncogene Proteins c-jun / biosynthesis*
  • Rats
  • Rats, Sprague-Dawley
  • Rotation
  • Stereotyped Behavior / drug effects
  • Transcription Factor AP-1 / metabolism*


  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-jun
  • Transcription Factor AP-1
  • Levodopa
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Dizocilpine Maleate
  • Benserazide
  • Oxidopamine