Isolated intracranial involvement in Rosai-Dorfman disease: a report of two cases and review of the literature

Arch Pathol Lab Med. 1998 Feb;122(2):161-5.


Rosai-Dorfman disease is an idiopathic histiocytic disorder of lymph nodes and extranodal sites. Central nervous system manifestations of this disease are rare, and to our knowledge only 16 cases of intracranial involvement have been reported previously. Intracranial Rosai-Dorfman disease clinically and radiologically resembles meningioma, and histologic examination is essential for a definitive diagnosis. We report two cases of isolated, intracranial, dural-based Rosai-Dorfman disease, review the literature, and discuss the differential diagnoses of this lesion.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Dura Mater / chemistry
  • Dura Mater / pathology*
  • Dura Mater / ultrastructure
  • Histiocytes / pathology
  • Histiocytosis, Sinus / diagnostic imaging
  • Histiocytosis, Sinus / immunology
  • Histiocytosis, Sinus / pathology*
  • Humans
  • Immunohistochemistry
  • Male
  • Meningioma / diagnosis
  • Microscopy, Electron
  • S100 Proteins / analysis
  • Tomography, X-Ray Computed


  • S100 Proteins