Prognostic accuracy of the mean of the largest nucleoli, vascular patterns, and PC-10 in posterior uveal melanoma

Ophthalmology. 1998 Mar;105(3):485-91. doi: 10.1016/S0161-6420(98)93032-9.


Objective: This study aimed to compare the prognostic value and the predictive accuracy of the PC-10 cell cycling marker with the largest tumor diameter, the mean of the largest nucleoli, and vascular patterns in posterior uveal melanoma.

Design: The study design was a case-control study.

Participants: Eyes enucleated for posterior uveal melanoma from patients who either died of metastatic melanoma or survived without signs of metastatic disease 10 years or more after surgery were studied.

Intervention: Three observers assessed the above prognostic indicators and standard histopathologic characteristics from microslides without access to survival data.

Main outcome measures: Univariate and multivariate Cox models for survival were constructed, and a multiparameter prognostic index was calculated for each patient, based on covariates obtained from the final Cox model. The prognostic accuracy was determined by receiver operating characteristic curve analysis.

Results: The log PC-10 count, vascular networks, mean of the largest nucleoli, largest tumor diameter, age of patient, and prognostic index were independently associated with outcome. However, each of these indicators had no more than a poor-to-moderate predictive accuracy, and only the prognostic index was significantly better than the largest tumor diameter.

Conclusions: The PC-10 count retains a prognostic value in uveal melanoma when adjusting for the effect of the mean of the largest nucleoli and diverse vascular patterns. A prognostic index combining two or more indicators may improve the predictive precision.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Neoplasm / analysis
  • Autoantigens / analysis
  • Cell Nucleolus / pathology*
  • Female
  • Humans
  • Male
  • Melanoma / blood supply*
  • Melanoma / mortality
  • Melanoma / pathology*
  • Middle Aged
  • Mitotic Index*
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Survival Rate
  • Uveal Neoplasms / blood supply*
  • Uveal Neoplasms / mortality
  • Uveal Neoplasms / pathology*


  • Antigens, Neoplasm
  • Autoantigens