In Situ Detection of Epstein-Barr Virus in Breast Cancer

Cancer Lett. 1998 Feb 13;124(1):53-7. doi: 10.1016/s0304-3835(97)00449-7.


Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / chemistry
  • Breast Neoplasms / virology*
  • Epstein-Barr Virus Nuclear Antigens / analysis*
  • Female
  • Herpesviridae Infections / metabolism*
  • Herpesviridae Infections / virology
  • Herpesvirus 4, Human*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Middle Aged
  • RNA, Small Nuclear / analysis
  • RNA, Viral / analysis
  • Tumor Virus Infections / metabolism*
  • Tumor Virus Infections / virology
  • Viral Matrix Proteins / analysis*


  • EBV-associated membrane antigen, Epstein-Barr virus
  • Epstein-Barr Virus Nuclear Antigens
  • RNA, Small Nuclear
  • RNA, Viral
  • Viral Matrix Proteins