Reduced angiogenesis and tumor progression in gelatinase A-deficient mice

Cancer Res. 1998 Mar 1;58(5):1048-51.


Matrix proteolysis is thought to play a crucial role in several stages of tumor progression, including angiogenesis, and the invasion and metastasis of tumor cells. We investigated the specific role of gelatinase A (matrix metalloproteinase 2) on these events using gelatinase A-deficient mice. In these mice, tumor-induced angiogenesis was suppressed according to dorsal air sac assay. When B16-BL6 melanoma cells or Lewis lung carcinoma cells were implanted intradermally, the tumor volumes at 3 weeks after implantation in the gelatinase A-deficient mice decreased by 39% for B16-BL6 melanoma and by 24% for Lewis lung carcinoma (P < 0.03 for each tumor). The number of lung colonies of i.v. injections fell by 54% for B16-BL6 melanoma and 77% for Lewis lung carcinoma (P < 0.014 and P < 0.0015, respectively). These results indicated that host-derived gelatinase A plays an important role in angiogenesis and tumor progression, suggesting the usefulness of gelatinase A inhibitors for anticancer chemotherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Division
  • Cell Movement / genetics
  • Gelatinases / deficiency*
  • Gelatinases / genetics*
  • Humans
  • Matrix Metalloproteinase 2
  • Melanoma, Experimental / blood supply
  • Melanoma, Experimental / genetics*
  • Melanoma, Experimental / pathology
  • Metalloendopeptidases / deficiency*
  • Metalloendopeptidases / genetics*
  • Mice
  • Mice, Mutant Strains
  • Neovascularization, Pathologic / genetics*


  • Gelatinases
  • Metalloendopeptidases
  • Matrix Metalloproteinase 2