Investigation of exocrine pancreatic function by continuous infusion of caerulein and secretin in normal subjects and in chronic pancreatitis

Digestion. 1976;14(2):97-107. doi: 10.1159/000197914.

Abstract

Exocrine pancreatic function has been evaluated in 24 controls and 29 patients with confirmed chronic pancreatitis by continuous infusion (90 min) of synthetic caerulein, 100 ng/kg/h, plus GIH secretin, 1 CU/kg/h. Mean secretory values of the controls were comparable to those obtained by others using maximal doses of secretin and CCK. Unlike the controls, patients suffering from chronic pancreatitis demonstrated a progressive reduction in secretion during infusion. Thus, the comparison of responses for the final 30-min period gave much clearer and more complete discrimination between normal and abnormal pancreatic function than the preceding 30-min period.

MeSH terms

  • Adolescent
  • Adult
  • Bicarbonates / metabolism
  • Ceruletide*
  • Chronic Disease
  • Chymotrypsin / metabolism
  • Female
  • Humans
  • Injections, Intravenous
  • Lipase / metabolism
  • Male
  • Middle Aged
  • Pancreas / metabolism*
  • Pancreatitis / physiopathology*
  • Secretin* / administration & dosage
  • Secretory Rate / drug effects
  • Trypsin / metabolism

Substances

  • Bicarbonates
  • Secretin
  • Ceruletide
  • Lipase
  • Chymotrypsin
  • Trypsin