Telomeres and senescence: the history, the experiment, the future

Curr Biol. 1998 Feb 26;8(5):R178-81. doi: 10.1016/s0960-9822(98)70105-8.


Telomere length has been proposed to signal entry into cellular senescence. Expression of the human telomerase subunit, hTERT, in primary cells now shows that these cells bypass senescence.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Humans
  • Telomerase / metabolism
  • Telomere / physiology*


  • Telomerase