Abstract
The CNC-basic leucine zipper (CNC-bZIP) family is a subfamily of bZIP proteins identified from independent searches for factors that bind the AP-1-like cis-elements in the beta-globin locus control region. Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1 and Nrf-2 are expressed in a wide range of tissues. To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Anemia / genetics*
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Animals
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DNA-Binding Proteins / analysis
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology*
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Embryonic and Fetal Development
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Erythropoiesis / genetics*
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Fetus
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Genes, Lethal / physiology*
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Homozygote
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Leucine Zippers
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Liver
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Mice
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Mice, Knockout
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Molecular Sequence Data
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NF-E2-Related Factor 1
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Nuclear Respiratory Factor 1
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Nuclear Respiratory Factors
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RNA, Messenger / analysis
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Trans-Activators / analysis
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Trans-Activators / genetics
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Trans-Activators / physiology*
Substances
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DNA-Binding Proteins
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NF-E2-Related Factor 1
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Nrf1 protein, mouse
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Nuclear Respiratory Factor 1
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Nuclear Respiratory Factors
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RNA, Messenger
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Trans-Activators