Bone fracture history and prospective bone fracture risk of hemodialysis patients are related to apolipoprotein E genotype

Calcif Tissue Int. 1998 Mar;62(3):278-81. doi: 10.1007/s002239900430.


This investigation of 219 hemodialysis patients relates the history and prospective risk of bone fractures to apolipoprotein E (apoE) genotype. A greater percentage of the 41 patients with the E3/4 and E4/4 genotypes than of the 38 patients with the E2/3 and E2/2 genotypes had a history of bone fractures at the time of recruitment (44% versus 16%, P < 0.005). During the 4 years following recruitment, more of the patients with apoE genotypes E3/4 and E4/4 than with apoE genotypes E2/3 and E2/2 suffered bone fractures, but this difference was not statistically significant (17.1 versus 5.3%, P < 0.1). ApoE genotype appears to be an important genetic risk factor for bone fracture, possibly due to its previously reported influence on vitamin K concentrations in blood.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Apolipoproteins E / genetics*
  • Apolipoproteins E / metabolism
  • Bone and Bones / injuries*
  • Female
  • Fractures, Bone / epidemiology
  • Fractures, Bone / etiology
  • Fractures, Bone / genetics*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Renal Dialysis*
  • Risk Factors
  • Vitamin K / genetics
  • Vitamin K / metabolism


  • Apolipoproteins E
  • Vitamin K