Increased plasma amyloid beta protein 1-42 levels in Down syndrome

Neurosci Lett. 1998 Jan 23;241(1):13-6. doi: 10.1016/s0304-3940(97)00966-x.

Abstract

Amyloid beta protein 1-40 (A beta40) and A beta42 levels were quantitated in plasma from 43 persons with Down syndrome (DS; 26-68 years of age), 43 age-matched normal controls, and 19 non-DS mentally retarded (MR) persons (26-91 years of age) by using a sandwich enzyme linked immunosorbent assay. A beta40 levels were higher in DS and MR than controls, but were similar between DS and MR groups. A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were higher in DS than controls or MR persons. The findings are consistent with those seen in DS brains.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides / blood*
  • Down Syndrome / blood*
  • Down Syndrome / genetics
  • Female
  • Gene Dosage
  • Humans
  • Intellectual Disability / blood
  • Intellectual Disability / genetics
  • Male
  • Middle Aged
  • Peptide Fragments / blood*
  • Trisomy

Substances

  • Amyloid beta-Peptides
  • Peptide Fragments
  • amyloid beta-protein (1-40)
  • amyloid beta-protein (1-42)