U-43,120; a new antitumor antibiotic. I. Production, biological activity, microbiological assay and taxonomy of the producing microorganism

J Antibiot (Tokyo). 1976 Jun;29(6):611-7. doi: 10.7164/antibiotics.29.611.

Abstract

A new antitumor antibiotic, U-43,120 was discovered. It is produced by fermentation of a new species of Streptomyces, designated Streptomyces paulus DIETZ sp. n. Its antimicrobial activity is limited to bacteria. A microbiological assay with Bacillus subtilis was developed that can be detect concentrations of 1 approximately 2 mug/ml of the drug in fermentation liquors. U-43,120 was active in vivo against P-388 leukemia in mice.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic* / biosynthesis
  • Antibiotics, Antineoplastic* / pharmacology
  • Antibiotics, Antineoplastic* / therapeutic use
  • Bacteria / drug effects
  • Fermentation
  • Leukemia, Experimental / drug therapy
  • Mice
  • Streptomyces / classification
  • Streptomyces / growth & development
  • Streptomyces / metabolism
  • Time Factors

Substances

  • Antibiotics, Antineoplastic