The glutamate antagonist riluzole suppresses intracortical facilitation

J Neural Transm (Vienna). 1997;104(11-12):1207-14. doi: 10.1007/BF01294721.


The effect of the glutamate antagonist riluzole on excitatory and inhibitory phenomena in the human motor system was studied by transcranial magnetic stimulation (TMS) and peripheral electrical nerve stimulation. The motor threshold, the intracortical inhibition and intracortical facilitation as assessed by paired TMS, the cortical and peripheral silent periods, F wave amplitudes and F wave latencies were measured. Riluzole suppressed the intracortical facilitation whereas other parameters remained unchanged, indicating that the neurotransmitter glutamate is mainly involved in facilitatory mechanisms in the motor system.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / physiology*
  • Electromagnetic Fields
  • Electrophysiology
  • Excitatory Amino Acid Antagonists / adverse effects
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Glutamic Acid / physiology*
  • Humans
  • Movement / drug effects
  • Movement / physiology
  • Peripheral Nervous System / drug effects
  • Peripheral Nervous System / physiology
  • Riluzole / adverse effects
  • Riluzole / pharmacology*
  • Spinal Cord / drug effects


  • Excitatory Amino Acid Antagonists
  • Glutamic Acid
  • Riluzole