Changes in protein kinase C and adenylate cyclase in the temporal lobe from subjects with schizophrenia

J Neural Transm (Vienna). 1997;104(11-12):1371-81. doi: 10.1007/BF01294738.


Changes in G-protein linked neurotransmitter receptors have been reported in a number of regions of the brain of schizophrenic subjects. These changes, if functional, could cause a change in proteins such as protein kinase C (PKC) and adenylate cyclase (AC) which are important components of the G-protein linked second messenger cascades. We therefore used autoradiography to measure the distribution and density of [3H]phorbol ester binding to PKC and [3H]forskolin binding to AC in tissue obtained at autopsy from schizophrenic and non-schizophrenic subjects (Controls). There were significant decreases in the density of PKC in the parahippocampal gyrus (687 +/- 60 vs. 885 +/- 51 fmol/mg TE; mean +/- SEM; p < 0.01) and in AC in the dentate gyrus (75 +/- 4.9 vs. 92 +/- 6.5, p < 0.05) from the schizophrenic subjects. These data could indicate that changes in neurotransmitter receptors in the hippocampus from subjects with schizophrenia could have resulted in a change in their associated second messenger systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenylyl Cyclases / metabolism*
  • Adult
  • Aged
  • Colforsin / pharmacokinetics
  • Female
  • Frontal Lobe / enzymology
  • Frontal Lobe / pathology
  • Hippocampus / enzymology
  • Hippocampus / pathology
  • Humans
  • Male
  • Middle Aged
  • Phorbol 12,13-Dibutyrate / pharmacokinetics
  • Protein Kinase C / metabolism*
  • Psychiatric Status Rating Scales
  • Schizophrenia / enzymology*
  • Schizophrenia / pathology
  • Temporal Lobe / enzymology*
  • Temporal Lobe / pathology


  • Colforsin
  • Phorbol 12,13-Dibutyrate
  • Protein Kinase C
  • Adenylyl Cyclases