A nonlinear multirigid body dynamic computer model has been developed to simulate the dynamic responses of a wheelchair-occupant system in a vehicle during a crash. The occupant, restrained by safety belts, is seated in a wheelchair that is, in turn, tied down in a vehicle. Validated extensively by crash sled tests at three laboratories, this model has been used to predict the responses of wheelchair-occupant systems in various crash environments. To evaluate the crashworthiness of different wheelchair tie-downs, the sensitivity of several design parameters, such as tiedown stiffness, wheel stiffness, and tiedown positions, has been studied using this model, and optimal values of these parameters for the wheelchair-occupant system have been obtained. Moreover, the model has been used to study the sensitivity of crash sled test pulse corridors in an effort to develop a sled test standard. It has been found that an existing ISO corridor allows large variation and should be "tightened." The model was implemented using a version of the multibody dynamic simulator, the Articulated Total Body program.