Thrombotic microangiopathy associated with cryoglobulinemic membranoproliferative glomerulonephritis and hepatitis C

Am J Kidney Dis. 1998 Mar;31(3):521-6. doi: 10.1053/ajkd.1998.v31.pm9506691.


Cryoglobulinemic membranoproliferative glomerulonephritis (MPGN) and increased incidence of vascular thromboses are complications of hepatitis C virus (HCV) infection. This report describes the clinical, laboratory, and renal biopsy findings in two HCV-positive patients with cryoglobulinemic MPGN and thrombotic microangiopathy (TMA). Testing for circulating antiphospholipid antibodies, which are detected in a significant proportion of patients with HCV, was negative in the one case in which it was done. This article discusses the possible cause of the TMA in these two cases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cryoglobulinemia / complications*
  • Female
  • Glomerulonephritis, Membranoproliferative / complications*
  • Hepatitis C / complications*
  • Humans
  • Kidney / blood supply*
  • Kidney Diseases / complications
  • Male
  • Microcirculation
  • Middle Aged
  • Thrombosis / complications*