Neuropeptide Y antibody attenuates 2-deoxy-D-glucose induced feeding in rats

Brain Res. 1998 Jan 19;781(1-2):348-50. doi: 10.1016/s0006-8993(97)01310-3.

Abstract

2-deoxy-D-glucose (2-DG) has been shown to induce increased feeding responses in animals. Recent studies suggest the possible involvement of neuropeptide Y (NPY) in 2-DG-induced feeding. The present study examined the effect of immunoneutralization of endogenous NPY on 2-DG-induced feeding. NPY antibody injected into the paraventricular nucleus of the rats significantly attenuated 2-DG-induced feeding, suggesting that hypothalamic NPY may mediate, at least partly, the effect of 2-DG on food intake.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Deoxyglucose / immunology
  • Deoxyglucose / pharmacology*
  • Feeding Behavior / drug effects*
  • Immune Sera
  • Male
  • Neuropeptide Y / immunology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Immune Sera
  • Neuropeptide Y
  • Deoxyglucose