Graft decentration in penetrating keratoplasty: nonmechanical trephination with the excimer laser (193 nm) versus the motor trephine

Ophthalmic Surg Lasers. 1998 Feb;29(2):106-13.


Background and objective: Graft decentration is an obvious cause of postkeratoplasty astigmatism. The purpose of this study was to compare graft decentration after nonmechanical trephination with the excimer laser (193 nm) with that after mechanical motor-trephination in 50 consecutive patients with Fuchs' dystrophy and 50 patients with keratoconus.

Patients and methods: To determine decentration in absolute values and clock hours, a postoperative slide was projected with a fixed magnification onto a pattern with circles corresponding to the trephination margin. Using a second transparent and movable pattern with concentric circles and ellipses, the authors measured the amount and direction of decentration relative to the limbus and to the pupil. In addition, the keratometric astigmatism and the refractive cylinder were assessed. In this prospective study, the patients were assigned randomly to either method of trephination.

Results: The decentration was significantly lower (P < .002) with excimer laser trephination (0.23 +/- 0.26 mm, relative to the limbus; 0.33 +/- 0.26 mm, relative to the pupil) than with mechanical trephination (0.58 +/- 0.23 mm, relative to the limbus [P < .01]; 0.64 +/- 0.24 mm, relative to the pupil [P < .005]). There was no significant difference between the results obtained in patients with Fuchs' dystrophy and those of patients with keratoconus. The preferred direction of decentration relative to the pupil was the lower quadrants. There was a mild correlation between net astigmatism and the absolute value of decentration. However, with sutures in place, there were no significant differences in the keratometric net astigmatism between mechanical and nonmechanical trephination (P = .16) or between Fuchs' dystrophy and keratoconus (P = .18).

Conclusions: The results indicate that the amount of decentration can be reduced by specific techniques associated with nonmechanical trephination. This might have a favorable impact on the residual astigmatism after suture removal.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Astigmatism / etiology*
  • Astigmatism / pathology
  • Astigmatism / prevention & control
  • Cornea / pathology*
  • Cornea / surgery
  • Female
  • Follow-Up Studies
  • Fuchs' Endothelial Dystrophy / surgery
  • Humans
  • Keratoconus / surgery
  • Keratoplasty, Penetrating / adverse effects*
  • Keratoplasty, Penetrating / methods*
  • Laser Therapy / methods
  • Male
  • Middle Aged
  • Prospective Studies
  • Pupil
  • Refraction, Ocular