Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone

Neurosci Lett. 1998 Jan 30;241(2-3):99-102. doi: 10.1016/s0304-3940(98)00010-x.


The superoxide (O2.-) scavenging activity and the neuroprotective effects of pterin-6-aldehyde (P6A), a xanthine oxidase inhibitor, were examined and compared with those of alpha-phenyl-N-tert-butyl nitrone (PBN), a spin trapping agent. The scavenging activity of P6A was more potent than that of PBN by 150-fold in neutrophil/phorbol myristate acetate O2.- generating system. P6A attenuated the neuronal damage with a much smaller dose and a greater efficiency than PBN in global brain ischemia in gerbils. These findings suggest that P6A is a more potent neuroprotective agent than PBN and has possible therapeutic effects against various diseases in which O2.- is involved.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Brain Ischemia / drug therapy*
  • Cyclic N-Oxides
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology
  • Free Radical Scavengers / pharmacology*
  • Gerbillinae
  • Male
  • Neurons / drug effects
  • Neuroprotective Agents / pharmacology*
  • Nitrogen Oxides / pharmacology*
  • Pteridines / pharmacology*
  • Pterins*
  • Spin Labels
  • Xanthine Oxidase / antagonists & inhibitors


  • Cyclic N-Oxides
  • Enzyme Inhibitors
  • Free Radical Scavengers
  • Neuroprotective Agents
  • Nitrogen Oxides
  • Pteridines
  • Pterins
  • Spin Labels
  • phenyl-N-tert-butylnitrone
  • 2-amino-4-hydroxy-6-formylpteridine
  • Xanthine Oxidase