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. 1998 Jan 12;100(1):85-101.
doi: 10.1016/s0047-6374(97)00121-8.

Trisomy 21 and Accelerated Aging: DNA-repair Parameters in Peripheral Lymphocytes of Down's Syndrome Patients

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Trisomy 21 and Accelerated Aging: DNA-repair Parameters in Peripheral Lymphocytes of Down's Syndrome Patients

N S Raji et al. Mech Ageing Dev. .

Abstract

Down's syndrome (DS) cases from 1-40 years of age and showing no other anomalies or deficiencies were categorized into three age groups: group 1, < or = 12 years; group 2, 13-25 years; and group 3, > or = 26 years. The DNA-repair markers like unscheduled DNA synthesis (UDS), activities of DNA polymerases, (Total, beta and epsilon) and two endodeoxyribonucleases, (UV- and AP-DNases) were assessed in the peripheral lymphocytes of these subjects (under different conditions) along with age and sex matched normal healthy human subjects. The DS group showed lower DNA-repair efficiency and also an accelerated decline in DNA-repair capacity with age. These results indicate that deteriorated DNA-repair potential could be one of the probable reasons for premature aging seen in this chromosomal disorder.

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