Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients

Mech Ageing Dev. 1998 Jan 12;100(1):85-101. doi: 10.1016/s0047-6374(97)00121-8.


Down's syndrome (DS) cases from 1-40 years of age and showing no other anomalies or deficiencies were categorized into three age groups: group 1, < or = 12 years; group 2, 13-25 years; and group 3, > or = 26 years. The DNA-repair markers like unscheduled DNA synthesis (UDS), activities of DNA polymerases, (Total, beta and epsilon) and two endodeoxyribonucleases, (UV- and AP-DNases) were assessed in the peripheral lymphocytes of these subjects (under different conditions) along with age and sex matched normal healthy human subjects. The DS group showed lower DNA-repair efficiency and also an accelerated decline in DNA-repair capacity with age. These results indicate that deteriorated DNA-repair potential could be one of the probable reasons for premature aging seen in this chromosomal disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aging / metabolism*
  • Carbon-Oxygen Lyases / metabolism
  • Child
  • Child, Preschool
  • DNA / biosynthesis
  • DNA Repair*
  • DNA-(Apurinic or Apyrimidinic Site) Lyase
  • DNA-Directed DNA Polymerase / metabolism
  • Deoxyribonuclease IV (Phage T4-Induced)
  • Down Syndrome / metabolism*
  • Endodeoxyribonucleases / metabolism
  • Humans
  • Infant
  • Infant, Newborn
  • Leukocytes, Mononuclear / metabolism
  • Multienzyme Complexes / metabolism
  • N-Glycosyl Hydrolases / metabolism


  • Multienzyme Complexes
  • UV endonuclease
  • DNA
  • DNA-Directed DNA Polymerase
  • Endodeoxyribonucleases
  • Deoxyribonuclease IV (Phage T4-Induced)
  • N-Glycosyl Hydrolases
  • Carbon-Oxygen Lyases
  • DNA-(Apurinic or Apyrimidinic Site) Lyase