Epstein-Barr virus infection and its role in the expanding spectrum of human diseases

Acta Paediatr. 1998 Jan;87(1):11-8. doi: 10.1080/08035259850157796.


Recent advances of the various laboratory tests to detect Epstein-Barr virus (EBV) infection have clarified the causative role for a spectrum of EBV-associated diseases. They include lymphoproliferative disorders (LPD), which occur in immunologically compromised individuals, Hodgkin's disease (HD), chronic active EBV infection (CAEBV), virus-associated hemophagocytic syndrome (VAHS), certain forms of T cell lymphoma, and some gastric carcinomas, in addition to the classical EBV-associated diseases such as EBV genome-positive Burkitt's lymphoma (BL), undifferentiated nasopharyngeal carcinoma (NPC) and infectious mononucleosis (IM). This review intends to introduce the recent progress of studies on EBV infection mainly from the clinical points of view.

Publication types

  • Review

MeSH terms

  • Animals
  • Burkitt Lymphoma / complications
  • Burkitt Lymphoma / diagnosis
  • Female
  • Herpesviridae Infections / complications*
  • Herpesviridae Infections / prevention & control
  • Herpesviridae Infections / therapy*
  • Herpesvirus 4, Human / isolation & purification*
  • Hodgkin Disease / diagnosis
  • Hodgkin Disease / etiology*
  • Humans
  • Infectious Mononucleosis / complications
  • Infectious Mononucleosis / diagnosis
  • Male
  • Mice
  • Nasopharyngeal Neoplasms / diagnosis
  • Nasopharyngeal Neoplasms / etiology*
  • Prognosis
  • Risk Assessment
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / etiology*
  • Tumor Virus Infections / complications*
  • Tumor Virus Infections / diagnosis