A case of severe neonatal lupus erythematosus without cardiac or cutaneous involvement

Acta Paediatr. 1998 Jan;87(1):105-7. doi: 10.1080/08035259850157994.


Neonatal lupus erythematosus is a disease primarily characterized by cardiac and/or cutaneous involvement. Liver and haematological involvement occur in a few cases and these are normally considered to be mild and transient complications. The disease is suspected to be caused by transplacental passage of maternal autoantibodies, primarily anti-Ro/SSA and anti-La/SSB, from mothers with systemic lupus erythematosus. Here we report a child with neonatal lupus erythematosus who died from severe liver and haematological disease when 2 d old. The baby had no cardiac or cutaneous involvement. The mother has had two subsequent pregnancies. In the first she had a boy without certain signs of neonatal lupus erythematosus. In the next pregnancy the child developed congenital complete heart block and cutaneous lesions.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Antinuclear / analysis
  • Cesarean Section
  • Fatal Outcome
  • Female
  • Heart Diseases / diagnosis
  • Humans
  • Infant, Newborn
  • Liver / pathology
  • Lupus Erythematosus, Cutaneous / diagnosis
  • Lupus Erythematosus, Systemic / congenital*
  • Lupus Erythematosus, Systemic / diagnosis*
  • Lupus Erythematosus, Systemic / immunology
  • Male
  • Multiple Organ Failure
  • Pregnancy
  • Pregnancy Complications / diagnosis*


  • Antibodies, Antinuclear