A plasmid-mediated beta-lactamase conferring resistance to cefotaxime in a Salmonella typhimurium clone found in St Petersburg, Russia

J Antimicrob Chemother. 1998 Jan;41(1):119-21. doi: 10.1093/jac/41.1.119.

Abstract

Four clinical and two environmental isolates of cefotaxime-resistant Salmonella typhimurium strains collected in St Petersburg, Russia, were studied. Molecular typing demonstrated that they constituted a single clone. The isolates expressed a cefotaxime-hydrolysing beta-lactamase with a pl of 8.4. The enzyme was encoded by a 12 kb plasmid which did not hybridize with TEM, SHV or ampC probes.

MeSH terms

  • Cefotaxime / pharmacology*
  • Cephalosporins / pharmacology*
  • Plasmids / genetics
  • Russia
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / enzymology
  • beta-Lactamases / drug effects*
  • beta-Lactamases / metabolism

Substances

  • Cephalosporins
  • beta-Lactamases
  • Cefotaxime