Immunologic abnormalities in scleroderma

Semin Cutan Med Surg. 1998 Mar;17(1):18-21. doi: 10.1016/s1085-5629(98)80057-6.


The immune system abnormalities of scleroderma are diverse and in association with vascular and mesenchymal cell abnormalities, contribute to the organ system dysfunction and clinical expression of the disease. Recent insights into novel immune regulatory pathways, immune reactivity to self-antigens, and the potential association of persistent fetal cells and disease expression may serve to increase our understanding of this enigmatic disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantigens / biosynthesis
  • Autoimmune Diseases / immunology*
  • Graft vs Host Disease / immunology*
  • Humans
  • Immunity, Cellular / physiology
  • Mice
  • Scleroderma, Localized / immunology*
  • Scleroderma, Systemic / immunology*


  • Autoantigens