Crohn's disease stable remission after human immunodeficiency virus infection

Dig Dis Sci. 1998 Feb;43(2):412-9. doi: 10.1023/a:1018883112012.


We retrospectively assessed the clinical course in four patients with long-standing Crohn's disease who became infected with human immunodeficiency virus (HIV). The duration of active Crohn's disease was 21, 10, 4, and 4 years in our four patients. They experienced a stable remission of Crohn's disease symptoms after HIV infection. In three patients Crohn's disease was in stable remission for 5, 8, and 8 years after HIV infection and all three died from acquired immunodeficiency syndrome-related disease. One patient was still alive without recurrence of Crohn's disease symptoms 7 years following HIV detection. Our observations of a spontaneous improvement in the clinical course of Crohn's disease after HIV infection, suggests that the integrity of the immune response, especially that of CD4 T cells, plays a major role in the tissue injury mechanism in Crohn's disease.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • CD4-Positive T-Lymphocytes / immunology
  • Crohn Disease / complications*
  • Crohn Disease / immunology
  • Fatal Outcome
  • Female
  • HIV Infections / complications*
  • Humans
  • Male
  • Retrospective Studies